However, it has been found that additional α-adrenergic blockade with carvedilol may increase the number of patients with hemodynamic responses resulting in a reduction in hepatic venous pressure ...

Two protocols for switching between carvedilol, a third-generation nonselective agent with vasodilation through α 1 blockade, and a β 1-selective agent (e.g., metoprolol, atenolol) are described ...