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生物通
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抗菌大环肽揭示 BamA 独特抑制模式,为抗耐药菌研究开辟新径
抗生素耐药性严重威胁全球健康,针对革兰氏阴性菌的新型抗生素研发停滞。研究人员通过 mRNA 展示技术筛选与大肠杆菌 BamA 结合的环肽,发现 3 种环肽能抑制 BAM 缺陷菌株生长、阻断外膜蛋白(OMP)组装。该研究为开发新型抗生素提供了方向。
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