Acetyl-CoA synthetase (ACS) is one of several enzymes that generate the key metabolic intermediate, acetyl-CoA. In microbes and mammals ACS activity is regulated by the post-translational acetylation ...

Targeting aldolase A to induce imbalanced glycolysis could overcome the intrinsic ... I in melanoma cells increases mitochondrial acetyl-CoA levels, leading to epigenetic activation of genes ...

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In addition to glycolysis, other metabolic pathways and metabolites are involved in EMT during ... Acetylation of histones is achieved by HATs which transfer acetyl groups from acetyl-CoA. To remove ...

Results: We found that there is a significant correlation between Lubben Social Network score and alterations in genes related to insulin resistance and glycolysis (FDR adjusted p <0.05).

Mechanistically, Acod1 suppressed osteoclast differentiation by inhibiting succinate dehydrogenase-dependent production of reactive oxygen species and Hif1α-mediated induction of aerobic glycolysis.

β-Oxidation of acyl-CoA to acetyl-CoA then occurs at the matrix ... The mitochondrial respiratory chain is the final common pathway for aerobic glycolysis and fatty acid oxidation. The respiratory ...

Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

The highest level of aerobic glycolysis was noted with a combination ... reduced extracellular lactate and increased total acetyl-coenzyme A (CoA) by changing glycolytic flux.

Migratory locusts display striking phenotypical plasticity. Gregarious locusts at high density can migrate long distances and cause huge economic losses of crops. By contrast, solitary locusts at low ...