CD4 + Foxp3 + T regulatory cells (Treg) are required throughout life to maintain a healthy immune system because conventional CD4 + T cells (Tconv) pose a permanent threat of deadly autoimmune attack ...

Tregs are primarily identified by the surface markers CD4 and the intracellular transcription factor forkhead box protein 3 (Foxp3), the latter being essential for their regulatory function (2).

Methods We compared Treg cells of patients with juvenile idiopathic arthritis responding or not to therapy by using: (i) T cell receptor (TCR) sequencing, to identify clonotypes shared between blood ...

Stationed within the meninges, squads of immune cells lie in wait, ready to unleash an inflammatory assault within the brain if needed. Holding these trigger-happy troops back during peacetime falls ...

21,24 First evidence that Treg reconstitution by IL-2 is clinically effective in SLE comes from a recent report showing a rapid and robust induction of clinical remission in parallel to a remarkable ...

Here, we report that the glycolytic enzyme phosphoglycerate mutase (PGAM), which converts 3-phosphoglycerate (3PG) to 2-phosphoglycerate (2PG), is physiologically upregulated in Tregs and its ...

在全球范围内，食物过敏是一种日益普遍的免疫疾病，可能导致严重的过敏反应和过敏性休克。然而，目前对于食物抗原耐受性失常和维持机制的了解仍然有限。由波士顿儿童医院的科研团队发表在《Nature》上的论文“RELMβ sets the threshold ...

Tregs in the brain’s protective layers regulate inflammation and help nerve cell regeneration Loss of Tregs leads to brain inflammation, memory impairment, and neuronal damage Understanding ...

The disease is also linked to female genital schistosomiasis, which can cause infertility, chronic pain, and increased susceptibility to sexually transmitted infections, including HIV. In the long ...