The mutant ataxin7 contributes to retinal degeneration through several mechanisms: accumulation of mutant protein and consequent toxicity to tissues, induced transcriptional perturbations on ...

This review evaluates recent research on PASC-related perturbations in animal models, drawing comparisons with clinical findings. Despite the limited number of studies on post-COVID conditions, ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Genome-wide association studies (GWASs) have ...

We identified six HSC states that are characterized by enrichment but not exclusive expression of marker genes. External signals induced rapid transitions between HSC states but transcriptional ...

To sum up, transcriptional activation by CRISPRa is able to reveal complex molecular networks and cell interactions where gene knockout can be too dashing. This will help to understand the process of ...

Its pathogenesis comprises subversion of transcriptional regulation, through mutation and by hijacking normal chromatin regulation. Kat2a is a histone acetyltransferase central to promoter activity, ...