2015). VTD enhances the transactivation of cytoplasmic UBXN2A, where UBXN2A binds and inhibits mot-2 oncoprotein. The combination of VTD with a suboptimal dose of the standard chemotherapy, ...

Mesenchymal stromal cell (MSC) metabolism plays a crucial role in the surrounding microenvironment in both normal physiology and pathological conditions. While MSCs predominantly utilize glycolysis in ...

Abelacimab is a fully human monoclonal antibody that binds to the inactive form of factor XI and blocks its activation. The safety of abelacimab as compared with a direct oral anticoagulant in ...

Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory for Digestive Health, National Clinical Research Center for Digestive Disease, Beijing ...

The methylation of plasma cell-free DNA (cfDNA) has emerged as a valuable diagnostic and prognostic biomarker in various cancers including colorectal cancer (CRC). Currently, there are no biomarkers ...

Using a series of deletion mutants comprising 2 kb up to 8 kb of the Cdx2 promoter, we found CDX2 transactivation of its own promoter in all the constructs. There was no obvious pattern of increasing ...