Another factor is the production of viral proteins (HBsAg, HBeAg), which function as a tolerogen and leads to T-cell exhaustion. [26] Advancement in the understanding of the mechanisms involved in ...
A pilot phase II trial conducted by Koffeman and colleagues tested the immunologic and clinical efficacy of administering the tolerogen DNAJP1 (a dominant epitope of the heat shock protein DNAJ ...
NIAID inventors have identified a multi-valent tolerogen (MMPt), which can specifically elicit RICD of the activated, disease causing autoimmune T cells without compromising the general T cell ...