Stem-cell differentiation is the process by which a more specialised cell is formed from a stem cell, leading to loss of some of the stem cell's developmental potential. Stem-cell differentiation ...

Downstream of the pre-BCR, SYK (spleen tyrosine kinase) has a central role in the activation of pathways that regulate the proliferation and differentiation of pre-B cells. In the context of ...

prospective isolation of “repair” Schwann cells for autologous cell transplants, which is hampered by supply challenges, and directed differentiation of pluripotent stem cells or lineage conversion of ...

As osteoclasts derive from the monocyte lineage, we hypothesised a role for Acod1 and its metabolite itaconate in osteoclast differentiation and arthritis-associated bone loss ... (N.Oc/B.Pm), bone ...

The three-signal model provides an empirical framework for innate instruction of adaptive immunity, but mainly discusses STAT-dependent cytokines in T cell activation and differentiation, while the ...

IL-17A, IL-17F and bimekizumab monoclonal antibodies were used to block IL-17 cytokine action. Results Recombinant IL-17A and IL-17F are pro-osteogenic with respect to hPDC differentiation. T helper ...

2 Virginia Commonwealth University Institute of Molecular Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA Correspondence to Dr Xiang-Yang Wang, Department of ...

Food allergy, or the aggressive immune system reaction following the consumption of a certain food or food ingredient, typically involves immunoglobulin E (IgE) antibodies and can be potentially ...

but lack the key characteristics of adaptive immune cells, namely an antigen-specific receptor. ILCs interact closely with IECs and fulfil an important role in early defence including wound healing, ...

Feb. 10, 2025 — Influenza A virus particles strategically adapt their shape -- to become either spheres or larger filaments -- to favor their ability to infect cells depending on environmental ...

Food allergies can be life-threatening due to the rapid and exaggerated immune response. While mucosal mast cells (MMCs) are excessively proliferated during food allergies, the precise mechanisms that ...

Feb. 4, 2025 — Research has shown that a potential new targeted therapy for childhood brain cancer is effective in infiltrating and killing tumor cells in preclinical models tested in mice.