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心衰中坏死样细胞死亡模式:病因影响及 RIP3 抑制的作用探究
在这种严峻的形势下,科学家们发现坏死样细胞死亡,如坏死性凋亡(necroptosis)和焦亡(pyroptosis),在心肌缺血 / 再灌注损伤以及各种病因导致的衰竭心脏中发挥着重要作用。这两种细胞死亡模式不仅会导致心肌细胞的大量损失,还会引发炎症反应,进一步加重心脏的损伤。因此,深入了解它们在 HF 中的作用机制,对于开发新的治疗方法至关重要。
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