CD8 + T cell exhaustion is defined by a unique transcriptional and epigenetic profile that is important to understand for the generation of immunotherapies to treat cancer. Research now shows how ...

Debilitating chronic fatigue syndrome creates conditions where a kind of immune cell that identifies and kills pathogens, known as a T cell, becomes exhausted, according to a new study that points ...

Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its frontline defenders—T cells—lose their ability to function effectively.

5 (4) A CAR controlled remotely via drugs and other small molecules puts the brakes on T cell activation and prevents exhaustion. 6,7 (5) The T cell receptor (TCR) is a protein complex that recognizes ...