This important study sheds light on the role of sphingolipids on the maturation of Parkinson's disease-associated Synphilin-1 inclusion bodies (SY1 IBs) on the mitochondrial surface in a yeast model ...

We postulate that SY1 IB matures by association with the mitochondrion membrane, and that sphingolipids stimulate the maturation via their membrane-modulating function and thereby protecting cells ...

The pharmaceutical industry has experienced a substantial revolution with the introduction of novel technologies as well as ...

By examining human metabolomic, lipidomic and genomic data, the team found that those who went on to develop type 2 diabetes had reduced levels of a kind of lipid known as sphingolipids in their ...

To test how sphingolipids were driving cancer growth, the team turned to an FDA-approved drug used to treat Gaucher disease-;a genetic disorder characterized by an impaired ability to break down ...

The findings suggest that lower levels of circulating very long chain sphingolipids could serve as an early indicator for the progression from gestational diabetes to type 2 diabetes. "These ...

Biological lipids are generated from ketoacyl and isoprene (CH2=C(CH3)CH=CH2) groups and include glycerolipids, sphingolipids, fatty acids and polyketides. Lipids play roles in energy storage ...

By examining human metabolomic, lipidomic and genomic data, the team found that those who went on to develop type 2 diabetes had reduced levels of a kind of lipid known as sphingolipids in their ...

By examining human metabolomic, lipidomic and genomic data, the team found that those who went on to develop type 2 diabetes had reduced levels of a kind of lipid known as sphingolipids in their ...

Antigen processing and presentation is the mechanism by which whole antigens are degraded and loaded onto MHC molecules for display on the cell surface for recognition by T cells. Both macrophages ...

Kim. In addition, the comprehensive profiling of biomolecular dysregulations in this study helped identify sphingolipids as a reliable biomarker of PFOS-induced neurotoxicity. This approach of ...

Del Poeta’s lab has been studying sphingolipids metabolism and signaling in fungal and mammals cells to identify new markers for early diagnosis and microbial enzymes/ molecules essential to cause ...