Figure 1. Schematic illustration of regulatory network that controls pluripotency, self-renewal and differentiation. SOX2, NANOG, and OCT4 regulate their own expression targeting both their own ...

First numbering (census) of the Israelites for military purposes and encampment location of each tribe in relation to the Tabernacle About 70 times in the Book of Numbers, we read: The Lord said or ...

Laboratory-induced arthritis models such as antigen-induced arthritis (AIA) and collagen-induced arthritis (CIA) are based on different immune pathways and show distinct pain-like behaviors and ...

Stemness gene OCT4 was identified as the new candidate gene downstream of the RBBP4/E2F1 signal pathway which was directly regulated by miR-429 ... which suggests that some unknown mechanism such as ...

Cancer stem cells are rare immortal cells within a tumour that can both self-renew by dividing and give rise to many cell types that constitute the tumour, and can therefore form tumours.

Therefore, some pathophysiological changes, especially those occurring in the upstream of the pathway, might only show up in a certain group of PD and not be shared by all PD cases. Identification of ...

The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide expert advice on some of the most pressing challenges facing the nation and world. Our ...

Importantly, this newly identified role of IκBα operates independently of its canonical function in inhibiting the NF-κB pathway. Our findings underscore the intricate interplay between inflammation ...