Dependent on a ubiquitin mark on the protein, they will be either recycled or sorted into intraluminal vesicles (ILVs) by endosomal sorting complex required for transport (ESCRT) proteins. During ...

To enable sorting, you must have either Nametags or Layout (or both) enabled. This is the default and recommended method. Players will be sorted by their primary permission group, according to the ...

Another intraendosomal sorting receptor of the LDL receptor family, SorLA, can bind and reroute receptors from the endosome back to the trans-Golgi network (TGN), where it is either sequestered, ...

Ubiquitylation is a reversible post-translational modification involved in a myriad of cellular functions. A superfamily of approximately 100 ubiquitin-specific proteases, called deubiquitylating ...

Hence, the coordinated action of multiple UBDs can be used to sort substrates towards specific functional pathways according to their ubiquitin chain linkage type. These findings have provided a ...

Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of diabetes. Microvascular endothelial cells are thought to be the major targets of hyperglycemic injury. In ...

(A) Meiosis II (MII) oocytes were fixed and co-stained with anti-RAB5 and anti-LAMP1 antibodies. The schematic diagram indicates the location of oocyte chromosomes and metaphase plate in the MII ...

Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong SAR 99999, China ...

This puts the kibosh on its travels into the endosome (Fazeli et al., 2024). Due to its sequestration in the ER ... Those related proteins include the low-density lipoprotein receptor (LDLR) and ...

That the lactyl mimic bound more tightly to CD2AP, an adaptor protein that regulates endosomal trafficking and sorting, likely explains these effects, the authors found. Levels of APP or BACE1 did not ...