One major challenge in making these improved lipids was the difficulty of creating branched ionizable lipids—key components of LNPs that change their charge to help them escape the endosome.

One major challenge in making these improved lipids was the difficulty of creating branched ionizable lipids -- key components of LNPs that change their charge to help them escape the endosome.

During the endosome–lysosome transition, the compartmental pH drops, which is conducive to the function of lysosomal acid hydrolases. Damaged lysosomes are eliminated by lysophagy, yet the ...

Using the Hubble Space Telescope (HST), astronomers from the University of California Santa Cruz (UCSC) and elsewhere have observed an ultra-diffuse galaxy known as FCC 224. Results of the ...