Activation-induced cytidine deaminase (AID) plays a crucial role in the immune system by facilitating somatic hypermutation (SHM) and class switch recombination (CSR) in B cells. These processes ...

Antibody drugs have reshaped how we treat diseases. By harnessing the immune system to destroy tumours or temper excessive inflammation in autoimmune disorders, these therapeutics have become ...

The current understanding of humoral immune response in cancer patients suggests that tumors may be infiltrated with diffuse B cells of extra-tumoral origin or develop organized lymphoid structures, ...

Induces potent and long-lasting immune responses to defined antigens or whole pathogens (particles), mainly through the ...

Results: BCR-seq of both twins revealed convergent antibody characteristics including V-gene use, CDRH3 lengths and somatic hypermutation (SHM). Further, antibody clonotypes with genetic features ...

The enormously complex, multifactorial and highly regulated cellular processes that generate receptor variation in somatic cells arose through the integration of molecular systems that are not ...

It is administered by subcutaneous and intravenous route. The drug candidate acts by targeting PD-1 immune checkpoint. It is developed based on the somatic hypermutation (SHM) platform. It was under ...

“Dr. Dennis Burton's group and others have shown that you require a substantial amount of somatic hypermutation over the context of many exposures to evolve these bNAbs. Work from Dr. Michel ...

Here, we provide an overview of the potential for chromosomal copy number changes, somatic nuclear and mitochondrial DNA mutations, single nucleotide polymorphisms, and T and B cell receptor sequences ...

Somatic symptom disorder (SSD) is a diagnosis that was introduced with publication of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) in 2013. It eliminated the ...