A recent paper in Nature sheds welcome light on the mechanism of somatic hypermutation by documenting the participation of double-strand DNA breaks. The antibody response, which occurs in ...

在线发表了题为“Molecular Mechanisms of DNA Lesion and Repair During Antibody Somatic Hypermutation”的综述文章。该综述全面总结了抗原特异性多样化抗体生成的 ...

Somatic hypermutation, gene conversion and class-switch recombination are genetic rearrangements that generate the molecular diversity of immunoglobulin genes underlying the human immune system. In ...