Here we address this question by examining regulatory elements of Srs2, such as its phosphorylation, sumoylation, and protein-interaction sites. Our genetic analyses and checkpoint level assessment ...

Regulatory features of Srs2 and corresponding mutants. (A) Schematic of Srs2 protein domains, regulatory features, and mutations affecting each of its features. Cdk1 phosphorylation sites depicted ...

【导读】SUMOylation在肿瘤发生过程中的重要性已受到越来越多的关注，针对这一途径的治疗药物研究也取得了进展。然而，SUMOylation在肝细胞癌 ...

June 10, 2024 — Scientists have grown 'mini-guts' in the lab to help understand Crohn's disease, showing that 'switches' that modify DNA in gut cells play an ... Major Cause of Inflammatory ...

Acute respiratory distress syndrome (ARDS) is present in >10% of all people admitted to critical care and is associated with severe morbidity and mortality. Despite more than half a century since its ...

Skeletal muscle (SKM) has crucial roles in locomotor activity and posture within the body and also functions have been recognized as an actively secretory organ. Numerous bioactive molecules are ...

Nov. 20, 2024 — A new study shows stimulating the vagus nerve in mice with colitis reduced stress-driven symptoms of inflammatory bowel disease by regulating SUMOylation, an immune response that ...

1 Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China 2 Zigong Hospital of Traditional Chinese Medicine, Zigong, China Mitochondria are important organelles that regulate ...