该研究是由上海交通大学医学院附属仁济医院消化科研究员洪洁及其团队主导，论文共同第一作者为仁济医院消化科硕士研究生王振宇，博士研究生蒋怡、宁立军，四川省人民医院消化内科医师、博士后朱小强以及中南大学湘雅三医院消化内科主任医师田力。中南大学湘雅三医院消化 ...

This study provides evidence that single-cell multi-omics profiling can reveal key regulators of HIV-1 persistence and early immune dysregulation, particularly implicating KLF2 and Th17 cells as major ...

Recludix Pharma, a leader in the discovery of inhibitors of challenging targets for inflammatory disease, today announced ...

Objectives NFIL3 is a key immunological transcription factor, with knockout mice studies identifying functional roles in multiple immune cell types. Despite the importance of NFIL3, little is known ...

However, the molecular basis underlying the transformation from metaplastic to cancerous cells remains poorly understood. Conclusions Our findings highlighted that KLHL21 loss triggers STAT3 ...

Mechanistic studies revealed that upregulated HLF transcriptionally enhanced interleukin 6 (IL-6) expression and intensified signal transducer and activator of transcription 3 (STAT3) phosphorylation, ...

p-STAT3的高活性可增加T细胞中转录因子RORgt的表达，进而降低Foxp3的表达，从而导致CD4+ T细胞分化为Th17细胞，而不是treg细胞。 TGF-b是一种由巨噬细胞和T细胞产生的多功能细胞因子，在免疫调节中起着关键作用。TGF-b主要通过调节T细胞亚群的发育和功能来发挥其 ...

STAT3是一种蛋白质，属于一个对控制转录至关重要的蛋白质大家族——将基因复制到RNA中以构建蛋白质的过程。STAT3对胚胎发育至关重要，也参与炎症过程、免疫系统激活和其他生物过程。 以色列理工学院的研究人员发现，在健康状态下（没有病毒感染），NORAD和 ...

Distant metastasis is associated with poorer prognosis and a higher mortality rate. Helper T lymphocyte 17 (Th17) cells and regulatory T lymphocytes (Tregs) play different roles in PTC, and the ...

In addition, TFs linked to the reciprocal differentiation to Th17 versus Treg cells were also found to play a crucial role in attenuation of GVHD. For example, recipients of T cells with a STAT3 ...