This important study reports single-nucleus multiomics-based profiling of transcriptome and chromatin accessibility of mouse XX and XY primordial germ cells (PGCs). The main conclusions of this study, ...

转录因子性别决定区Y相关高迁移率群盒基因9 （SOX9）在器官发育中起着至关重要的作用。 转录因子性别决定区Y相关高迁移率群盒基因9 （SOX9）在器官发育中起着至关重要的作用。尽管SOX9在体外参与调节脂质代谢，但其在代谢功能障碍相关脂肪性肝炎（MASH ...

This valuable study reports single-nucleus multiomics-based profiling of transcriptome and chromatin accessibility of mouse XX and XY primordial germ cells (PGCs). Solid data generally support the ...

Researchers have uncovered how a SOX9 switch determines the successful regeneration of kidney cells. When kidney tissues are damaged there are two outcomes. Either the damage is temporary – whereby ...

SOX9, a member of the SRY-related HMG-box transcription factors, has been reported to critically regulate fetal development and stem cell homeostasis. Wnt signalling is a highly conserved signalling ...

Background: Evidence exists uncovering that SRY-box transcription factor 9 (SOX9) plays a role in ischemic brain injury (IBI). Thus, the current study was conducted to elucidate the specific role of ...