The snRNAs can be divided into two classes on the basis of common sequence features and protein cofactors. Sm-class RNAs ... snRNPs prior to their assembly into the spliceosome.

In human cells, only a small proportion of the information written in genes is used to produce proteins ... is just the first step in the spliceosome's complex assembly pathway.

In human cells, only a small proportion of the information written in genes is used to produce proteins ... spliceosome has evolved to use additional non-canonical base-pairing interactions to fulfil ...

In human cells, only a small proportion of the information written in genes is used to produce proteins ... is just the first step in the spliceosome's complex assembly pathway.

Membrane protein trafficking in eukaryotes relies on dozens of protein complexes that recruit cargoes, drive vesicle budding, and catalyze vesicle fusion. While the biological roles of these membrane ...

Together, these snRNAs and proteins form small nuclear ribonucleoprotein particles (snRNPs), setting the stage for splicing. 1 The traditional view posits that spliceosome formation is a stepwise ...

Splicing is a basic requirement for producing proteins that fulfill an organism's vital functions. Researchers have succeeded for the first time in depicting a faultily 'blocked' spliceosome at ...

The outcome varies depending on which parts are cut out, resulting in distinct blueprints for different proteins. This process is crucial for the life of the cell. "The spliceosome is composed of ...