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综述:TIGIT/PVR 轴在血液系统恶性肿瘤中调节抗肿瘤免疫
TIGIT 和 DNAX 辅助分子 1(DNAM1,CD226)都能与 PVR 结合,但亲和力和功能不同。TIGIT 作为抑制性受体,亲和力较高,与 PVR 结合后会招募 SHIP1,阻断 PIK - 3、NF - κB 或 MAPK 信号通路,抑制 NK 和 T 细胞介导的细胞毒性,还与 NK 和 T 细胞耗竭相关。T 细胞耗竭会使其杀伤 ...
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