Pancreas cells may produce a protein that can protect the brain from Alzheimer's disease. In individuals with Alzheimer's disease, a peptide known as amyloid-β accumulates and forms tangled plaques.
In the process, they discovered the role of an enzyme, a special E3 ligase that joins a small protein modification called UFM1 to the large ribosomal subunit, as a key mechanism of recycling.
Specifically, ribosomal "junk" proteins, produced when things go wrong inside the nucleolus. "[Nucleolar stress causes cells to] reduce their capacity to produce new proteins," lead researcher ...