we noted that there were many cells containing acid-fast granules in the cytoplasm, around the granulomatous collections, in the connective tissue and in relation to small capillaries in both ...

IT has been demonstrated that, besides heparin and histamine, mast cells contain serotonin (5-hydroxytryptamine, 5-HT) 1–3. However, serotonin-containing mast cells, having been found ...

They release chemicals in response to allergens, which cause common allergy symptoms like tissue swelling and inflammation. Mast cells have a secret ability that researchers at ...

1–7 In particular, an association between some of the connective-tissue diseases and ... antinuclear antibody in 71 per cent, L.E. cells in 10 per cent and thyroglobulin antibodies in 14 per ...

We hypothesize that thalamic mast cells contribute to inflammation and pain, by releasing neuro-sensitizing molecules that include histamine, IL-1β, IL-6 and TNF, as well as calcitonin-gene related ...

Tissue-resident immune cells reside in distinct niches across organs, where they contribute to tissue homeostasis and rapidly respond to perturbations in the local microenvironment. Innate lymphoid ...

Anti-inflammatory medications are a cornerstone of treatment for mixed connective tissue disease (MCTD) but your diet also is important ... In a study on type 1 diabetes, researchers found that a ...

Patients with connective tissue diseases who experienced COVID-19-related hospitalization, severe inpatient stays, and mortality were predominantly older and men. Using glucocorticoids, rituzimab, or ...

Pathogen-fighting immune cells called tissue-resident memory CD8 T cells (TRM cells) go through a surprising transformation -- and relocation -- as they fight infections in the small intestine.

A corticosteroid-sensitive TAC1 signature was developed from the TAC1 ICS-responsive genes. This signature consisted of mast cell-specific genes identified by single-cell RNA-sequencing and positively ...

Researchers have developed a way of bioprinting tissues that change shape as a result of cell-generated forces, in the same way that it happens in biological tissues during organ development.