Figure 2. Crosstalk between the GPCR and JAK2-STAT5 signaling pathways. AC, adenylyl cyclase; cAMP, cellular adenosine 3’,5’-cyclic monophosphate; GPCR, G protein-coupled receptor; JAK2, Janus kinase ...

Because mutations of this receptor or its ligand lead to autoimmune disorders such as systemic lupus erythematosus (SLE) and cancers, CD95 and CD95L were initially thought to play a role in immune ...

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase ... in the activation of several downstream pathways that are shared with other tyrosine kinases. Many of these pathways have already ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

Verastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with RAS/MAPK pathway-driven cancers, today announced its 2025 priorities and upcoming ...

to stimulate distinct signaling pathways via p125-focal adhesion kinase towards actin regulation and towards Mer receptor tyrosine kinase, both indispensable for engulfment. Furthermore, we found that ...

Endosomes have emerged as major signaling hubs where different internalized ligand-receptor complexes are integrated and the outcome of signaling pathways are organized to regulate the strength and ...

Sorafenib is an oral tyrosine kinase inhibitor able to inhibit VEGF receptors 1, 2 and 3, PDGF receptors α and β, RET, Flt3, c-KIT and the RAF kinase and MAPK pathways. Over 10,000 patients have ...

However, mechanistic studies to support the conclusion that mitochondrial function is increased in the tumours remain incomplete and would benefit from experiments that would directly interrogate ...

Tyrosine kinases are important elements of signal transduction pathways that transmit ... are the mutations detected in the kinase growth factor receptors Kit, Fms, or FLT3. Also, these mutations ...

D tumoroid models transform cancer research, accurately reflecting tumor biology and enabling effective drug testing and ...