Figure 2. Crosstalk between the GPCR and JAK2-STAT5 signaling pathways. AC, adenylyl cyclase; cAMP, cellular adenosine 3’,5’-cyclic monophosphate; GPCR, G protein-coupled receptor; JAK2, Janus kinase ...

Because mutations of this receptor or its ligand lead to autoimmune disorders such as systemic lupus erythematosus (SLE) and cancers, CD95 and CD95L were initially thought to play a role in immune ...

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase ... in the activation of several downstream pathways that are shared with other tyrosine kinases. Many of these pathways have already ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

to stimulate distinct signaling pathways via p125-focal adhesion kinase towards actin regulation and towards Mer receptor tyrosine kinase, both indispensable for engulfment. Furthermore, we found that ...

Sorafenib is an oral tyrosine kinase inhibitor able to inhibit VEGF receptors 1, 2 and 3, PDGF receptors α and β, RET, Flt3, c-KIT and the RAF kinase and MAPK pathways. Over 10,000 patients have ...

However, mechanistic studies to support the conclusion that mitochondrial function is increased in the tumours remain incomplete and would benefit from experiments that would directly interrogate ...

such as increasing the function of oestrogen receptor-α and E2F1, the activity of the insulin-like growth factor 1 (IGF1) signalling pathway, epidermal growth factor receptor (EGFR) and ERBB2 ...

Consecration and 10 steps to cleansing. They do dovetail with our responsibilities. What is required of a priest and how does the priesthood parallel with those who are Christians? Can you draw a ...

Data from the Phase 3 PALOMA-3 study showed non-inferiority to intravenous administration meeting both co-primary pharmacokinetic (PK) endpoints, as well as a five-fold reduction in infusion-related ...