Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase ... in the activation of several downstream pathways that are shared with other tyrosine kinases. Many of these pathways have already ...

and how these receptor on-off signals switch the kinase on and off. The resulting molecular mechanisms are likely conserved throughout the diverse family of 2-component pathways, which control most ...

The study uncovers a novel mechanism by which ING5 promotes the phosphorylation of pyruvate dehydrogenase kinase 1 (PDK1) at tyrosine 163 ... identified a novel signaling pathway involving ...

The study uncovers a novel mechanism by which ING5 promotes the phosphorylation of pyruvate dehydrogenase kinase 1 (PDK1) at tyrosine 163 ... identified a novel signaling pathway involving ...