However, this approach does not address transcriptome complexity in alternative splicing and transcription termination sites; presumably further sequencing can reveal additional variants. As RNA ...

What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

The realization that most human genes generate multiple mRNAs encoding divergent protein isoforms via alternative splicing and polyadenylation has revealed extensive regulation that remains to be ...

They can also be within the exon.” RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence ...

RNA splicing is a cellular process that is critical ... is more complicated than it is in some model organisms like yeast, ...

Get Instant Summarized Text (Gist) Researchers have identified a method to reactivate a molecular "kill switch" in cancer cells by targeting alternative RNA splicing. Cancer cells suppress poison ...

The researchers tested the RNA origami in a lipid vesicle, a simple cell model system widely used in biology. Using so-called RNA aptamers, the artificial cytoskeleton was bound to the cell membranes.

Arrakis’s DM1 drug program represents a rationally designed small molecule genetic medicine directed at a pathogenic RNA to achieve reversal of myotonia in an animal model of DM1. Utilizing the ...