Palbociclib, a well-tolerated and selective CDK4/6 inhibitor, has shown promising results in the treatment of retinoblastoma (RB1)-positive breast cancer. RB1 is rarely mutated in HCC, suggesting that ...

This valuable study reports a chemogenetic screen for resistance and sensitivity to three cell cycle inhibitors used in the clinic: camptothecin, colchicine, and palbociclib. The screen provides a ...

The study by Longhurst et al. investigates the mechanisms of chemoresistance and chemosensitivity towards three compounds that inhibit cell cycle progression: camptothecin, colchicine, and palbociclib ...

The Seahawks used back-to-back second-round picks on running backs in 2022 and 2023. In 2022, they selected Ken Walker III 41st overall out of Michigan State to replace the retiring Chris Carson ...

p27 proteolysis is initiated by several different mechanisms. Tyrosine (Tyr) phosphorylation of p27 by Abl and Src family kinases reduces p27–CDK2 inhibition and transforms p27 from inhibitor to ...

Mitophagy is a type of autophagy that can selectively eliminate damaged and depolarized mitochondria to maintain mitochondrial activity and cellular homeostasis. Several pathways have been found to ...

Natural products have been extensively applied in clinical practice, characterized by multi-component and multi-target, many pharmacodynamic substances, complex action mechanisms, and various ...

Dr. Moyle and Dr. Mitchell answer criticisms of their interpretation of tests of the hypothesis proposed by Dr. Mitchell in 1961 to explain ATP synthesis in the inner membrane of mitochondria and ...

Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumor that poses a major hazard to people's health. ZC3H12D, which belongs to the family of CCCH-type zinc finger-containing ...

7 Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China Objective Hepatocellular carcinoma (HCC) is heterogeneous, especially in multifocal tumours, ...