Here the authors characterise THAP1 as a transcriptional activator of PSMB5, suggesting that proteasome dysfunction might underlie the pathogenesis of THAP1 dystonia.

Objectives To determine whether the process of ubiquitination and/or activity of the 26S proteasome are involved in the induction of osteoarthritis (OA). Methods Bovine cartilage resorption assays, ...

Nurix Therapeutics, Inc. stock slid 40% after promising NX-5948 results in CLL. NX-5948 shows efficacy in heavily pre-treated ...

The proteasome is crucial for protein degradation, and its dysfunction is linked to various pathologies. Here, the authors show that the transcription factor THAP1, the causative gene for DYT6 ...

Hong Kong Department of Health accepts IASO Bio’s NDA for equecabtagene autoleucel to treat r/r multiple myeloma: Shanghai, Nanjing Monday, February 17, 2025, 17:00 Hrs [IST] IA ...