However, it has proved difficult to engineer inhibitors of cysteine, serine or threonine proteases that do not contain an irreversible mechanism-based electrophile. This could be a matter of trial ...

Subjects were recruited in the Infectious Disease Clinic based on plans for initiation of protease inhibitor treatment. All subjects had normal routine laboratory screening results including ...

After Discontinuation of Treatment with QRX003 Complete Reversal of Positive Clinical Improvements Across all Measured Endpoints Observed; Data Supports QRX003 Mechanis ...

While performing a high-throughput screen (HTS) that identified the hits that led to the discovery of TNG908 and TNG462, we embarked on a structure-based design effort to switch the mechanism of ...

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article.

MCF7, MDA-MB-231 and Rosi cells were treated with Compound 1 or Compound 2 at a concentration of 20 µM in complete medium, and lysates were harvested after 2, 4, 6, 8 and 12 h in ...

In summary, enalapril significantly mitigated multiple pathological markers associated with aging, including lipid droplets, amyloid, glycogen deposition, and fibrosis, in the brain, kidneys, liver, ...

Biodiversity-derived molecules, namely those extracted from medicinal plants, are promising sources of toxin inhibitors that can minimize the deleterious consequences of SBEs. In this review, we ...

Pseudoscience has recently re-emerged in the U.S. While much of it concerns vaccines, an "oldie" is again making the rounds: HIV is neither the cause nor the sole cause of AIDS. This nonsense has been ...

Atherosclerotic cardiovascular disease is a major health concern worldwide and requires effective preventive measures. Lp(a) (lipoprotein [a]) has recently garnered attention as an independent risk ...