However, it has proved difficult to engineer inhibitors of cysteine, serine or threonine proteases that do not contain an irreversible mechanism-based electrophile. This could be a matter of trial ...

Food indeed contributes to the pharmacokinetic variability of protease inhibitors (PIs). [1] The exact mechanism(s) are poorly understood. As determined by measuring the area under the ...

Subjects were recruited in the Infectious Disease Clinic based on plans for initiation of protease inhibitor treatment. All subjects had normal routine laboratory screening results including ...