The GLP-1 receptor agonist exenatide failed to meet its primary outcome in a phase III trial of Parkinson's disease patients.

Parkinson's disease is a progressive disorder that develops when the brain cells that produce dopamine (a chemical involved in movement) stop working or die. When this happens, symptoms like slowed ...

The GLP-1 drug, exenatide, has no positive impact on the movement, symptoms or brain imaging of people with Parkinson's, finds a new study led by UCL researchers.

especially in the nigrostriatal pathway. The main consequence on motor symptoms or disease progression might depend on the different subtypes involved in such processes. Thus, there is not enough ...

npg.wustl.edu Objectives: Degeneration of nigrostriatal neurons and subsequent striatal ... and disease severity affect the physiology of dopaminergic pathways, producing altered responses to levodopa ...

14, 2025 — There may be a link between hearing impairment and an increased risk of developing Parkinson's ... linked disease-related proteins and genes to identify specific cellular pathways ...

Parkinson's disease (PD) and atypical Parkinsonian syndromes are progressive heterogeneous ... positron emission tomography for quantifying nigrostriatal functions, glucose metabolism, amyloid, tau ...

the test is able to identify early signs of Parkinson’s disease in individuals who have not yet shown clinical symptoms, potentially offering a new pathway for earlier intervention and improved ...

Dec. 18, 2024 — Dancing lowers the depression associated with Parkinson's disease, and the benefits can be seen in multiple ways, a new study ... Nov. 19, 2024 — A recently published study ...

People with Parkinson's disease are more likely to develop certain types of dementia. Find out about the causes, symptoms and treatments. Parkinson’s disease is a brain disease that affects around 145 ...

Parkinson's ... disease-modification, at least in the short-term. PD is a complex neurodegenerative disorder in which many different pathophysiological processes have been identified in the ...