Katalytic Therapeutics Inc. has divulged proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to a phosphodiesterase PDE4-targeting ...

The condition is usually caused by mutations in a gene called SMN1, which contains instructions for how to make a protein called survival motor neuron (SMN) protein.This protein is critical for ...

A two-and-a-half-year-old girl shows no signs of a rare genetic disorder, after becoming the first person to be treated for the motor-neuron condition while in the womb. The child’s mother took ...

Three experienced annotators labeled each neuron independently and then compared their labeled results to produce a final consensus as the GT. The ABO dataset consists of neuronal population imaging ...

Mar. 14, 2025 — Researchers have revealed a new scientific clue that could unlock the key cellular pathway leading to devastating neurodegenerative diseases like ...

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive memory loss and overall cognitive decline (McKhann et al., 2011) and is highly heritable (heritability 58–79%) ...

which acts as a PDE4 inhibitor. Results from the POETYK PSO-1 and POETYK PSO-2 showed that 58% and 53% respectively of patients treated with Sotyktu achieved 75% skin clearance, versus 35% and 40% ...

Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, ...

人原代主动脉外膜成纤维细胞专用培养基由团队精心优化，经过长期测试，本产品可保持人原代主动脉外膜成纤维细胞最佳的生长状态。 本产品中已包含人原代主动脉外膜成纤维细胞生长所需的各种成分，无需添加任何成分，可直接用人原代主动脉外膜成纤维 ...