The drug is cleared by cytochrome P450 (CYP)3A4 metabolism. Peak plasma concentrations are achieved about 1.5 hours after oral administration. Its absorption is not affected by food. Eplerenone ...

Cytochrome P450 3A4 interaction. Abuse potential (monitor). Life-threatening respiratory depression; monitor during initiation or following a dose increase. COPD, cor pulmonale, decreased ...

Opioid analgesic risk evaluation and mitigation strategy (REMS); Cytochrome P450 3A4 interaction. Assess the potential need for access to naloxone when initiating and renewing therapy. Consider ...

After oral administration, pravastatin undergoes extensive first pass metabolism in the liver but metabolization is not carried out by the cytochrome P450 3A4 enzymes system to a clinically ...