After oral administration, pravastatin undergoes extensive first pass metabolism in the liver but metabolization is not carried out by the cytochrome P450 3A4 enzymes system to a clinically ...
The drug is cleared by cytochrome P450 (CYP)3A4 metabolism. Peak plasma concentrations are achieved about 1.5 hours after oral administration. Its absorption is not affected by food. Eplerenone ...
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