Elinogrel (PRT060128 or PRT128) (Figure 3) is a direct-acting, reversible P2Y 12 antagonist (Figure 5) that can be administered both intravenously and orally. This unique dual formulation provides ...

P2Y 12 inhibitor‐based single antiplatelet therapy (SAPT) after drug‐eluting stent implantation reduces major bleeding without increasing the risk of major adverse cardiovascular and cerebral events ...

Biogen Inc. has disclosed uracil nucleotide/cysteinyl leukotriene receptor (GPR17; P2Y-Like) antagonists with improved brain penetration reported to be useful for the treatment of multiple sclerosis.

Purinergic signaling encompasses four adenosine receptors, eight P2Y receptors that respond to various extracellular nucleotides, and trimeric P2X receptors that respond mainly to ATP. Each organ and ...

The Prescription Drug User Fee Act (PDUFA) date refers to the deadline set by the US Food and Drug Administration (FDA) for reviewing a New Drug Application (NDA) or Biologics License Application (BLA ...

此前的研究虽发现 COVID-19 与广泛的炎症变化有关，且小胶质细胞（中枢神经系统实质中的主要炎症细胞）在患者大脑中出现形态转变和炎症特征，但 SARS-CoV-2 感染、中枢神经系统炎症和小胶质细胞表型变化之间的具体联系却尚不明确。正是在这样的背景下，研究人员开展了此次意义重大的研究，试图揭开 COVID-19 相关神经异常机制的神秘面纱。

医生们会为患者精心制定治疗方案，其中高强度他汀类药物治疗，如使用瑞舒伐他汀（rosuvastatin），以及 P2Y 12 受体拮抗剂（如替格瑞洛 ticagrelor、普拉格雷 prasugrel、氯吡格雷 clopidogrel）的联合应用是常用策略。这一组合就像是治疗心血管疾病的 “黄金搭档 ...

The key targets in the Coronary Artery Disease (CAD) (Ischemic Heart Disease) pipeline products market include P2Y Purinoceptor 12, Platelet Glycoprotein VI, and Hepatocyte Growth Factor. The key ...