Elinogrel (PRT060128 or PRT128) (Figure 3) is a direct-acting, reversible P2Y 12 antagonist (Figure 5) that can be administered both intravenously and orally. This unique dual formulation provides ...

P2Y 12 inhibitor‐based single antiplatelet therapy (SAPT) after drug‐eluting stent implantation reduces major bleeding without increasing the risk of major adverse cardiovascular and cerebral events ...

Biogen Inc. has disclosed uracil nucleotide/cysteinyl leukotriene receptor (GPR17; P2Y-Like) antagonists with improved brain penetration reported to be useful for the treatment of multiple sclerosis.