Immunotherapy. 2014;6(1):51-57. Broadly neutralizing antibodies have also been tested on maternal and infant HIV-1 variants, to determine their efficacy on mother to child transmission.

Broadly neutralizing antibodies (bNAbs) were first discovered in the '90s when it was observed that HIV-infected individuals possessed antibodies that could recognize and neutralize different subtypes ...

Get Instant Summarized Text (Gist) An HIV vaccine candidate has been developed that effectively guides immune cells to evolve into broadly neutralizing antibodies (bnAbs). In mouse studies, the ...

Antibodies mediate a broad array of non-neutralizing Fc-mediated functions against HIV-1 including antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP).

More information: Olivia M. Swanson et al, An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations, Science ...

ACTG, a global clinical trials network focused on HIV and other infectious diseases, today announced the opening of the ACACIA study (Antiretrovirals ...

"These antibodies actually make no direct contact ... response and improve the ability for vaccines to directly neutralize HIV. It also could lead to changes in HIV vaccine schedules, potentially ...

The development of an effective HIV vaccine remains an urgent public health need due to the high genetic variability and rapid mutation rates of the virus, which limit the generation of broadly ...

The study found that some of the newly identified antibodies could potently neutralize specific sarbecoviruses, while others displayed moderate neutralization but a broader range of activity. Further ...

The results showed that the immunogen successfully activated diverse precursors of what's known as an HIV V3-glycan broadly neutralizing antibody -- antibodies that target a crucial vulnerability ...