医院迅速与妇产科联系，为童童安排了紧急手术切除肿瘤，同时开始免疫治疗，包括免疫吸附、激素冲击、丙种球蛋白中和抗体等一系列治疗。幸运的是，经过20余天的积极治疗，童童的脑脊液抗体滴度逐渐下降，意识恢复正常，精神状态也明显好转，已经可以准备出院。

自身免疫性脑炎（AE）是一种由自身免疫机制介导的脑炎，通常与抗神经元细胞表面或者突触蛋白的自身抗体有关。抗N-甲基-D-天冬氨酸受体自身免疫性脑炎（NMDAR-AE）是最常见的AE类型，主要影响儿童和青年人群，且以女性为主。由于部分NMDAR-AE患 ...

抗髓鞘少突胶质细胞糖蛋白免疫球蛋白G抗体（MOG-IgG）相关疾病（MOGAD）合并抗N-甲基-D-天冬氨酸受体（NMDAR）脑炎是一种罕见的、复杂的重叠综合征（MNOS），由于其发病机制尚不明确且具有较高的复发风险，临床治疗面临巨大挑战。泰它西普作 ...

今年夏天，14岁的初中生小花（化名）突然出现怪异的言行：总说耳边有手机声在唱歌，时而无故大哭大笑，甚至出现抽搐昏迷不醒。在辗转多家医院后，在湖南省第二人民医院（省脑科医院）神经内科一病区涂鄂文主任医师团队确诊为“抗NMDAR脑炎，卵巢畸胎瘤”。这种极 ...

Background Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis rarely causes visible lesions in conventional MRI, yet advanced imaging detects extensive white ...

近日，湖南省第二人民医院（省脑科医院）儿科收治了一位特殊患儿。童童正值豆蔻年华，急起行为异常，感觉自己的大脑在燃烧，不知道自己在哪儿，说有人卖小孩，逐渐意识不清，出现不自主动作。

We demonstrate that the mature neurons express functional NMDARs exhibiting ligand-activated calcium flux, and we document the presence of NMDAR-mediated electrically evoked postsynaptic current. In ...

The NSAS are not well studied yet but T cell infiltration is less conspicuous in the few reports of patients with anti-NMDAR encephalitis.4 6 8 Another novel NSAb has been recently described against ...

华声在线3月12日讯 (通讯员 洪小平 张巧如 全媒体记者 邓桂明)去年夏天，14岁的初中生小花 (化名)突然出现怪异的言行，总说耳边有手机声在唱歌，时而无故大哭大笑，甚至出现抽搐昏迷不醒。在辗转多家医院后，近日在湖南省第二人民医院确诊为"抗NMDAR脑炎，卵巢畸胎瘤"，这种极易被延误的疾病，正在威胁青少年的健康。

“These findings suggest that non-ionotropic NMDAR signaling through GluN2B may represent a novel therapeutic target for the treatment of fragile X and related causes of intellectual disability ...

"It's been suggested for over a decade that the drug blocks a specific kind of NMDA receptor (NMDAR), called GluN1-2B-2D." There was one big problem with this theory. Scientists weren't quite sure ...

“Even putting this aside, many questions remain regarding how ketamine affects the brain,” says Furukawa. “It’s been suggested for over a decade that the drug blocks a specific kind of NMDA receptor ...