The AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and kainate types of GluRs were blocked by adding 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX) at a concentration of 5 ...

This important study characterizes and validates a new activity marker - fast labelling of engram neurons (FLEN) - which is transiently active and driven by cFos, allowing the monitoring of intrinsic ...

The mechanism of action underlying ketamine’s rapid antidepressant effects in patients with depression, both suffering from major depressive disorder (MDD) and bipolar disorder (BD), including ...

以前的研究发现，神经元活动和胶质瘤的发展之间有着千丝万缕的联系。神经元可以通过旁分泌信号，就像是细胞之间传递的 “小纸条”，来影响胶质瘤的进程。而且，神经元和胶质瘤细胞之间还存在着特殊的连接 —— 神经元 - 胶质瘤突触，这就好比是它们之间的 “秘密通道”，谷氨酸能 AMPA 受体依赖的突触在儿童和成人的高级别胶质瘤中都被证实存在。不过，除了谷氨酸之外，由其他神经递质介导的神经元 - ...