综合上述研究结果，研究人员发现恩格列净可以通过减弱肾脏和脂肪组织中的 AGE - RAGE - ROS（活性氧）轴，改善肥胖型 2 型糖尿病小鼠的肾脏和代谢紊乱。血清 MG - H1 水平可能是 2 型糖尿病肾脏和代谢紊乱的生物标志物。这一研究结果为 SGLT2i ...

反刍动物瘤胃中氨的生成速度快，氨同化的速度慢，这导致氨很容易在瘤胃中累积。若瘤胃氨浓度过高，部分过量的氨被运输至肝脏，通过鸟氨酸-尿素循环再次转化为尿素排出体外，不仅降低了氨利用效率［10］，还可能造成反刍动物氨中毒［3, ...

近日，杭州师范大学基础医学院郭瑞庭教授团队联合中国科学院天津工业生物技术研究所高书山研究员团队，采用单颗粒冷冻电镜技术在麦角生物碱生物合成关键酶EasC研究上取得新突破。

On track to report initial data from Phase 1/2 clinical trial of PM359 for p47phox CGD in 2025 -- -- IND-enabling studies ongoing for PM577 for Wilson's Disease; expect to file IND and/or CTA in ...

On track to report initial data from Phase 1/2 clinical trial of PM359 for p47phox CGD in 2025 -- -- IND-enabling studies ...

A GREEN ferment with peroxidase activity named 'verdoperoxidase' was isolated from leucocytes in 1941, the amount present in cells being estimated as 1–2 per cent 1. Verdoperoxidase seems to be ...

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Engineering Research Center of Ministry of Education on Food Synthetic Biotechnology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, China Science Center for Future Foods, Jiangnan ...

Cell membrane receptors are important therapeutic targets in many diseases, including cancer. The efficacy of targeted protein degraders of intracellular proteins, such as proteolysis-targeting ...