Monocytes are attracted by chemokines and specific receptors to precise areas in vessels or tissues and transdifferentiate into macrophages with tissue damage or infection. Adherent monocytes and ...

and provide insights into the fundamental differences between tissue-resident macrophages and adult monocyte-derived macrophages that reside in blood circulation (Davies et al., 2013). However, due to ...

Osteoclasts derive from a myeloid progenitor that gives rise to both the monocyte-macrophage lineage and the osteoclast lineage. A mononuclear pre-osteoclast exists that expresses both TRAP and CTR.

zju.edu.cn Objective Macrophages are among the most abundant cells in the colon tumour microenvironment, and there is a close relationship among monocytes, macrophages and the gut microbiota ...

PPAR-γ is prominently expressed in activated monocytes ... effects in macrophages. Here, we report that PPAR-γ is not essential for the development of the macrophage lineage in vitro and in ...

Design Flow cytometry, immunohistochemistry, confocal imaging and gene expression analyses determined the phenotype, functional/transcriptomic profile and tissue topography of MerTK+ ...

Using lineage ... macrophages (RPM), initially depleted by BCG exposure, are restored from both tissue-trained, self-renewing macrophages and from bone marrow-derived progenitors, fostering long ...

This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...

The absence of compatibility of the system human leukocyte antigen 1 (HLA-1) between the recipient and the donor is a very important determinant of rejection. When there are antibodies in the ...

2 Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology RAS, Moscow, Russian Federation Objectives Neutralisation of tumour necrosis ...

Neurons that secrete the neuropeptide orexin help mice decide between exercise and snacking.