2007; Shoulders et al., 2013). Through the combined IRE1α/PERK/ATF6 signaling axes, the adaptive UPR ER phase represents a rapid response to promote protein quality control and allow the resumption of ...

Mitochondrial dysfunction is involved in numerous diseases and the aging process. The integrated stress response (ISR) serves as a critical adaptation mechanism to a variety of stresses, including ...

Mitochondria have developed their own mechanisms (such as the one present in the endoplasmic reticulum, ER) to respond to this proteostatic stress, called the mitochondrial Unfolded Protein Response ...

These compounds were specific to the ISR and did not activate the unfolded protein response or the heat shock response. Kinases activated in the ISR were systematically depleted by CRISPRi revealing ...

In plants, the endomembrane system is tightly regulated in response to environmental stresses for maintaining cellular homeostasis ... Here, we have applied immunoprecipitation followed by tandem mass ...

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity ...

There are many high-protein vegetables you can add to your diet. Protein is needed to build and maintain healthy muscles, bones, and skin. Animal products are not the only high-protein food ...

Getting enough protein daily is essential for your overall health. Healthy protein sources include eggs, nuts, lean meats, fish, dairy, and certain grains. Proteins are a large category of ...