Studies of mismatch repair protein function will improve our ... mechanism invariably present a 'looping model' in which MSH proteins form a complex with MLH proteins to bind mismatched ...

Mutation or dysregulation of tumour-suppressor proteins can lead to unregulated cell growth and tumour development. Tumours with deficient DNA mismatch repair (dMMR) leading to a microsatellite ...

The evidence, they say, suggests that these proteins can contribute to suppression ... of immunotherapy outcome in deficient mismatch repair metastatic colorectal cancer, Clinical Cancer Research ...