Figure 3: The Dnmt1-interacting region of HDAC1 associates with methyltransferase activity. We transiently transfected 293T cells in culture dishes (15-cm diameter) with pCMV-Myc-Dnmt1 (20 μg ...

本综述全面剖析了SETD6在表观遗传调控中的作用，揭示其在转录控制、细胞生物学及疾病中的复杂机制（SETD6） SETD6（SET domain-containing protein 6）作为一种单甲基转移酶，在表观遗传调控中发挥着关键作用。它通过甲基化修饰多种转录因子和其他蛋白质，影响基因 ...

Unlike animals, plants do not possess an adaptive immune system with antibodies or T cells to fight viral infections. Instead ...

In the Protein Engineering and Evolution Unit's latest publication in Nucleic Acids Research, the team presents an engineered RNA methyltransferase, which can be used to study the role of RNA ...

New protein arginine N-methyltransferase 5 (PRMT5) inhibitors are detailed in a Scinnohub Pharmaceutical Co. Ltd. patent and described as potentially useful for the treatment of cancer.

Work at Purdue Research Foundation has led to the identification of prodrugs of nicotinamide N-methyltransferase (NNMT) inhibitors reported to be useful for the treatment of cancer.