The following is a summary of “Histone Modifications and DNA Methylation in Psoriasis: A Cellular Perspective,” published in the January 2025 issue of Allergy and Immunology by Pan et al. Epigenetic ...

is essential for regulating gene expression and protein function without altering the DNA sequence, contributing to various biological processes, including gene transcription, embryonic development, ...

The histone lysine methyltransferase DOT1L (DOT1-like histone lysine methyltransferase) is responsible for the epigenetic regulation of gene expression through specific methylation of lysine79 residue ...

Epigenetic changes can switch genes on or off and determine which proteins are transcribed ... treatments aim to alter either DNA methylation or histone acetylation. Inhibitors of DNA methylation ...

Metabolism can change when an acetyl group attaches to lysine in a mitochondrial protein (acetylation). The addition of a methyl group to histone peptides (methylation) regulates gene expression. And ...

An organism has multiple, cell type-specific, epigenomes comprising epigenetic marks such as DNA methylation ... accessibility, histone modifications and targeted proteins. We developed PRINT ...

She has spent most of her career counseling patients with diabetes, across all ages. Protein is needed to build and maintain healthy muscles, bones, and skin. Although we most commonly associate ...

Researchers discovered a molecular timer that gets activated in the first days of pregnancy and influences when mice give ...

Objectives To identify novel DNA methylation sites significant for rheumatoid arthritis (RA) and comprehensively understand their underlying pathological mechanism. Conclusions This multistage study ...

Methylation at H3K4 promotes transcription of genes near the histone, and marking H3Q5 with a serotonin helps maintain that methylation and gene expression. Marking H3Q5 with a histamine does the ...

Here, we aimed to explore the precancerous nature of IM by analysing epigenetic alterations. Design Genome-wide DNA methylation analysis was conducted by EPIC BeadArray using IM crypts isolated by ...

Erlebacher and his lab group were studying a protein called KDM6B which regulates ... winds down,” Erlebacher explained. “When histone methylation erodes enough, nearby genes flip on.” ...