Cornell researchers have identified a specific brain circuit that could lead to anxiety treatments without cognitive side ...

Weill Cornell Medicine investigators have identified in a preclinical model a specific brain circuit whose inhibition appears ...

Among the many compounds under investigation, NMDA and metabotropic glutamate receptor antagonists and negative allosteric modulators appear particularly promising due to their ability to inhibit ...

A brand new candidate for weight-loss treatment is on the table, with scientists uncovering for the first time how a hormone ...

and it will also work on a metabotropic glutamate receptor subtype 7 negative allosteric modulator (NAM). Both are in preclinical development. Other companies working on PAMs include Cerevel ...

Results and Discussion: The first part of the study demonstrated a decreased level of glutamate receptors in rats exposed to 14 days of RS, following an initial increase observed after 7 days of RS.

Increasing gamma-aminobutyric acid (GABA) and balancing glutamate, brain chemicals called neurotransmitters ... They don't cause neurotransmitter levels to rise but instead increase activity by ...