1 – 3 This clinical effect strongly supports the notion that B cells play a critical role in the pathogenesis of RA, although the exact mechanism of rituximab treatment in RA remains to be elucidated.

few data regarding the mechanisms of action of rituximab in autoimmune disease are available. The subepithelial deposition of IgG on the glomerular basement membrane, in response to unknown ...

The question of putative mechanisms of action continues to haunt psychopharmacology. Put simply, we know these drugs work, but we have very little idea how. We make guesses based on the ...

few data regarding the mechanisms of action of rituximab in autoimmune disease are available. Box 2. Immune effects of B-cell depletion by rituximab. Evidence that rituximab affects production of ...

However, despite LAG3’s role in immune exhaustion and the great potential of LAG3 inhibition as treatment, much remains unknown about its biology, particularly its mechanism of action. This review ...

The results provided new ideas and directions for treatment and drug development in the future. Various methods were used to analyze the characteristics, mechanism of action, and targets of ...

Conclusions A good clinical response to rituximab in RA is associated with a selective drug-induced increase in type I IFN-response activity in patients with RA. This finding may provide insight in ...

Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, National Clinical Research Center for ...

Even though there are indications of the health-promoting and cell-protective properties of ergothioneine, the underlying mechanism of action was previously unknown. "Our analyses now finally ...

The Clean Development Mechanism (CDM), defined in Article 12 of the Protocol, allows a country with an emission-reduction or emission-limitation commitment under the Kyoto Protocol (Annex B Party) to ...

Defense mechanisms are rooted in Freud’s theory of personality.According to his model, the mind has three dueling forces: the id (unconscious and primitive urges for food, comfort, and sex), the ...