Our results showed an increase in the percentage of MMP-13-positive cells in PPARγ KO mice compared with control mice at 10 weeks post-OA surgery (figure 2E, F). Further, qPCR analysis on isolated ...

Following the one-way analysis of variance test, Duncan’s multiple range test was used to examine percentage data (total motility, forward progressive motility, kinematic parameters, sperm viability, ...

The MMPs of all samples were visualised by zymography and tear samples were assayed using nitrophenol acetate and an MMP-9 susceptible quenched fluorescent peptide as substrate. RESULTS The major MMPs ...

To date, no study has used cultivation, qPCR, and DNA sequencing concurrently to confirm the existence of a microbiota in human amniotic fluid during normal pregnancy. The concurrent use of multiple ...

In summary, enalapril significantly mitigated multiple pathological markers associated with aging, including lipid droplets, amyloid, glycogen deposition, and fibrosis, in the brain, kidneys, liver, ...

The transcription factor of neuraminidase 3 (NEU3) of DEGs was verified by double luciferase reporting experiment, DNA pulldown, electrophoretic mobility shift assay and chromatin ...

Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China Core Unit of National Clinical Research Center for Laboratory Medicine, Peking University Third Hospital, ...

该研究表明，PROS1 在膀胱癌中表达下调，与不良预后相关。PROS1 通过影响细胞增殖、侵袭、迁移和血管生成，在膀胱癌发展中起关键作用，其调控作用可能通过 AKT/GSK3β/β - catenin 信号通路介导。这一发现揭示了 PROS1 作为膀胱癌潜在治疗靶点的重要价值，为膀胱癌的治疗提供了新的方向。

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Cancers display cellular, genetic and ...

Legumain 在癌症中的作用复杂多样，在不同肿瘤中表现出不同的预后意义。在 ccRCC 中，其蛋白水平在肿瘤组织中升高，但成熟形式减少，且尿中水平与肿瘤转移状态相关，这表明其细胞定位的调节可能参与 ccRCC 的恶性进展。Legumain 的分泌和功能受到多种因素的调控，包括氧化还原状态、翻译后修饰等。本研究发现的 His343 氧化位点在 prolegumain ...