Alteration in the expression of methyl-CpG-binding protein 2 (MeCP2) has been linked to a number of neurological disorders, including Rett syndrome (RTT). A recent modifier screen in flies has ...

In 1999, we discovered that Rett syndrome is caused by mutations in the gene encoding methyl-CpG-binding protein 2 (MECP2). Located on the X chromosome, MECP2 encodes a protein that binds methylated ...

Rett syndrome is a rare genetic disease affecting 1 in 10,000 newborn girls, characterized by sudden regression around 1 year ...

This disables the production of MeCP2 protein in all cells, as males have only one X chromosome. In humans with Rett, this ...

The team focused on engineering the parasites to deliver the MeCP2 protein, which is already seen as a promising treatment for Rett syndrome, a debilitating neurological disorder caused by ...

Researchers at the Josep Carreras Leukaemia Research Institute revealed a new aspect of Rett Syndrome’s pathogenesis that can ...

New research brings scientists one step closer to understanding Rett Syndrome, a rare genetic disease that affects 1 in ...

Of the many therapeutic proteins they engineered into Toxoplasma, only a few—including MeCP2 and transcription factor EB, which may help counteract neurodegeneration—successfully hitched a ride with ...

Upon hearing crying pups, mice with PVin lacking the MECP2 protein (bottom row) experience a dramatic increase in PNN number and intensity, especially on day one of the experiment (middle column).

MECP2 mutations are the major genetic mutation associated with Rett syndrome. Diagnosis is made via observable features, which include regression of developmental features, including language and ...